RESUMO Introdução: A hepatite C pode ser definida como uma doença infecciosa, que se desenvolve por uma atividade inflamatória, que pode gerar um comprometimento no Sistema Nervoso Central, podendo ocasionar prejuízos cognitivos e sintomas de depressão. Objetivo: O objetivo deste estudo foi verificar o desempenho cognitivo de pacientes com hepatite C crônica antes e após o tratamento com simeprevir, sofosbuvir e daclatasvir. Métodos: Foi realizado um estudo prospectivo em três etapas: antes, logo após o tratamento e seis meses depois. Foram avaliados 58 pacientes em acompanhamento clínico no Instituto de Infectologia Emílio Ribas, em São Paulo, Brasil. Foram utilizados os seguintes instrumentos: questionário sociodemográfico, Escala de Lawton, Inventário de Depressão de Beck e uma bateria de testes neuropsicológicos que avaliaram: função intelectual, memória, atenção, função executiva e velocidade motora e de processamento). Para análise estatística, foram utilizadas as análises descritas (média, frequência e desvio padrão), qui-quadrado e ANOVA. Resultados: A maioria dos participantes era do sexo masculino (n=30, 51,7%), com média de 58,23±8,79 anos, escolaridade média de 9,75±4,43 anos. Comparando os resultados das avaliações neuropsicológicas (antes, logo após a finalização dos medicamentos e seis meses), observou-se melhora significativa em relação à aquisição de novos conhecimentos (p=0,03), memória visual tardia (p=0,01) e tendência em relação a atenção alternada (p=0,07). Conclusão: O tratamento do vírus da hepatite C melhorou o desempenho cognitivo, principalmente em relação à memória.

ABSTRACT Background: Hepatitis C can be defined as an infectious disease that develops an inflammatory activity, which may cause an impairment in the central nervous system, may cause cognitive impairments and symptoms of depression. Objective: The objective of this study was to verify the cognitive performance of patients with chronic hepatitis C before and after treatment with simeprevir, sofosbuvir, and daclatasvir. Methods: A prospective study was carried out in three stages: before, right after treatment, and six months after. Fifty-eight patients under clinical follow-up were evaluated at the Emílio Ribas Infectology Institute, in São Paulo, Brazil. The following instruments were used: sociodemographic questionnaire, Lawton’s Scale, Beck’s Depression Inventory, and a battery of neuropsychological tests that evaluated: intellectual function, memory, attention, executive function, and motor and processing speed). For statistical analysis, the analyses described (mean, frequency, and standard deviation), chi-square, and ANOVA were used. Results: Most of the participants were male (n=30, 51.7%), with a mean of 58.23±8.79 years, mean schooling of 9.75±4.43 years. Comparing the results of neuropsychological evaluations (before, just after completion of drugs, and six months), a significant improvement was observed in relation to the acquisition of new knowledge (p=0.03), late visual memory (p=0.01), and tendency towards alternate attention (p=0.07). Conclusion: The treatment of the hepatitis C virus improved cognitive performance, especially in relation to memory.

The HAM/TSP caused by HTLV-1 infection usually affects patients to disabling states, and sometimes can lead them to paraplegia presenting symptoms of depression and anxiety, impacting on quality of life. Objective: The purpose of this study was to evaluate the frequency of depression and anxiety and its impact on quality of life in HTLV-1-infected TSP/HAM patients. Material and Methods: This was a cross-sectional study including 67 asymptomatic (control group) and 63 with TSP/HAM subjects. The instruments used were a demographic questionnaire, scales for anxiety and depression diagnosis (BDI and BAI), questionnaire for the assessment of Quality of Life of the World Health Organization (WHOQOL-Brief) and neurological scale to measure the disability level (Osame's Disability Status Scale). All patients had HTLV-I diagnosis by serological and molecular approaches, monitored at Instituto de Infectologia Emílio Ribas from May 2008 to July 2009. Data were analyzed statistically by frequencies, the Mann-Whitney test and the Spearman correlation test. Data among groups were analyzed and correlated with functional and severity aspects. Results: The results showed that patients with HAM/TSP compared to asymptomatic carriers had higher rates of depression (p < 0.001) and anxiety (p < 0.001), and impairment on quality of life in the areas of: dissatisfaction with health (p < 0.001), physical (p < 0.001) and the environment (p = 0.003). The main factors that correlated with levels of depression and anxiety and the domains of the WHOQOL-brief were: education, family income and social class. Conclusion: A well conducted evaluation and counseling may help in treatment, for a better quality of life of these patients.

Este trabalho pretende estudar a validade concorrente entre o 16PF - Questionário Fatorial da Personalidade e o BBT - Teste de Fotos de Profissões. O BBT é um teste projetivo, que se destina à apreensão do perfil de inclinação profissional, considerando oito fatores pulsionais. Apesar de o BBT ter sido concebido para adolescentes, estudos recentes mostraram que também pode ser empregado em adultos no contexto da orientação de carreira, coaching e seleção de pessoal. Enquanto o 16PF teve sua origem na análise fatorial, a construção do BBT se baseou nos pressupostos teóricos de Szondi sobre a estrutura pulsional das doenças mentais, com base em estudos clínicos com pacientes psiquiátricos. Embora os dois instrumentos partam de pressupostos teóricos muito diferentes, a estrutura fatorial do 16PF se assemelha em grande parte aos fatores pulsionais avaliados pelo BBT. Participaram do estudo 87 profissionais (35 homens e 52 mulheres) oriundos de diversas empresas, com idade média de 29,4 anos (DP=8,2). Os resultados confirmaram as hipóteses de pesquisa no nível de significância 0,05.

This work has the presentation of the result of the convergent correlation research between 16PF - The Sixteen Personality Factor Questionnaire and the BBT - Profession Photos Test as objective. The BBT is a projective test destined to apprehend the vocational profile for the purpose of vocational guidance, considering eight drive needs or factors. Although the BBT was designed to be used with adolescents, recent work has shown that it is also useful in the context of career counseling coaching and selection of employees. While the 16PF had its origin in the factorial analysis, BBT’s development is based on Szondi’s theoretical framework, the drive theory of mental diseases, created upon clinical research with psychiatric patients. Although both instruments are based on very different theories, the factorial structure of the 16PF resembles largely to the drive factors evaluated in BBT. The participants were 87 employees (35 men and 52 women) derived from navigation companies and costal traffic, chemical and information technology segments, aged around 29,4 years (SD=8,2). The results obtained in the correlation study confirmed the hypotheses to the convergence between both instruments at the significance level of 0,05.

Este trabajo pretende estudiar la validez concurrente entre el 16PF - Cuestionario Factorial de la Personalidad y el BBT - Prueba de Fotos de Profesiones. El BBT es una prueba proyectiva, que se destina a la aprehensión del perfil de inclinación profesional, considerando ocho factores impulsivos. A pesar del BBT haber sido concebido para adolescentes, estudios recientes mostraron que también puede ser empleado en adultos en el contexto de la orientación de carrera, coaching y selección de personal. Mientras el 16PF tuvo su origen en el análisis factorial, la construcción del BBT se basó en los presupuestos teóricos de Szondi sobre la estructura de impulso de las enfermedades mentales, con base en estudios clínicos con pacientes psiquiátricos. Aunque los dos instrumentos partan de presupuestos teóricos muy diferentes, la estructura factorial del 16PF se asemeja en gran parte a los factores de impulso evaluados por el BBT. Participaron del estudio 87 profesionales (35 hombres y 52 mujeres) oriundos de diversas empresas, con edad Media de 29,4 años (DP=8,2). Los resultados confirmaron las hipótesis de pesquisa en el nivel de significación 0,05